Dr Amira Hassouna

Senior Lecturer Interprofessional Health Studies

Phone: 09 9219999 ext.7314

Email: amira.hassouna@aut.ac.nz

Physical Address:

North Shore Campus
90 Akoranga Drive
Northcote
North Shore City

Postal Address:

Mail No. A-25
Private Bag 92006
Auckland 1142
New Zealand

ORCID: ORCID logo  https://orcid.org/0000-0002-3288-2402

Qualifications:

  • MB BCh of Medicine and Surgery Faculty of Medicine, Cairo University.
  • MSc and MD Medical Biochemistry Faculty of Medicine, Cairo University.
  • Postgraduate certificate in Health Sciences Health Professional Education from AUT University.

Memberships and Affiliations:

  • Australian Institute of Medical Scientists (AIMS).
  • AUT University, Faculty of Health and Environmental Sciences, School of Interprofessional Health Studies.
  • Cairo University, Faculty of Medicine, Department of Medical Biochemistry and Molecular Biology.

Biography:

I have been working for 20 years in the field of Medical and Applied Biochemistry and Molecular Biology (Teaching, Practicing and Publishing international scientific papers). I have been the Principal Investigator of a Hepatocellular Carcinoma project. I was a member of a scientific team at the Faculty of Medicine Cairo University, where I work as a professor, we carried out several projects conducting research and publishing papers in distinguished specialized international journals. I moved to NZ in Dec 2013 (skilled migrant category), during 2014 I started undertaking a postgraduate certificate in health professional education from AUT; completed in 2015. In July 2015 I was appointed to a senior lecturer position at AUT University.

My research interest has been directed to treat one of the most widespread diseases; diabetes mellitus, as well as one of the leading causes of cancer deaths worldwide; hepatocellular carcinoma, using natural compounds as Curcumin or regenerative treatment with stem cells. A disadvantage of Curcumin is that it is hard for the body to absorb, and it is rapidly cleared from the body. Generation of a “super curcumin” by increasing its bioavailability through making it more water soluble is the approach that was used in my research to test bringing this promising natural compound to the forefront of therapeutics of diabetes. The possible molecular mechanism of action of the antidiabetic effect of curcumin was also investigated.

My research also investigated the possible effect of Stem Cells on some signalling pathways in cancer and the results suggested that they modulate key signalling pathways and could be considered as a therapeutic target in Hepatocellular Carcinoma. Our results were sought by specialized organizations.

Teaching Areas:

Medical Biochemistry, Molecular biology, Human anatomy and physiology

Research Areas:

Medical Biochemistry, Molecular biology, Nutraceuticals and Stem cell research.

Publications:

  1. Anti-proliferative and anti-apoptotic potential effects of epigallocatechin-3-gallate and/or metformin on hepatocellular carcinoma cells: in vitro study. Sabry, D., Abdelaleem, O.O., El Amin Ali, A.M. et al. Mol Biol Rep,2019. https://doi.org/10.1007/s11033-019-04653-6
  2. Fucoidan Extracted from the New Zealand Undaria pinnatifida—Physicochemical Comparison against Five Other Fucoidans: Unique Low Molecular Weight Fraction Bioactivity in Breast Cancer Cell Lines. Mar. Drugs 2018, 16, 461.
  3. Breast carcinoma is a multifactorial disease involving FOXN3, SINA3 and NEAT through repression of GATA3 and TJP, Journal of Thoracic Disease, 2018, vol. 10, no. 3, pp. 1167-1171.
  4. Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro, Chinese Medicine, 2014 (United Kingdom), vol. 9, no. 1, pp. 1-12.
  5. Dose-dependent bioavailability indicators for curcumin and two of its novel derivatives,BioFactors, 2014, vol. 40, no. 1, pp. 132–137.
  6. Pilot study on molecular quantitation and sequencing of endometrial cytokines gene expression and their effect on the outcome of in vitro fertilization (IVF) cycle, Journal of Advanced Research, 2014, vol. 5, no. 5, pp. 595–600.
  7. The role of sex hormones in induced-systemic inflammation in female albino rats, Acta Physiologica Hungarica, 2014, vol. 101, no. 1, pp. 112–127.
  8. Effect of mesenchymal stem cells and a novel curcumin derivative on notch1 signaling in hepatoma cell line, BioMed Research International, 2013.
  9. Effect of novel water soluble curcumin derivative on experimental type- 1 diabetes mellitus (short term study), Diabetology and Metabolic Syndrome, 2012, vol. 4, no. 1.
  10. Amelioration of murine Schistosoma mansoni induced liver fibrosis by mesenchymal stem cells, Journal of Stem Cells and Regenerative Medicine, 2012, vol. 8, no. 1.
  11. Association between ghrelin levels and BMD: A cross sectional trial, Gynecological Endocrinology, 2012, vol. 28, no. 7, pp. 570–572.
  12. Efficacy of mesenchymal stem cells in suppression of hepatocarcinorigenesis in rats: Possible role of Wnt signaling, Journal of Experimental and Clinical Cancer Research, 2011, vol. 30, no. 1.
  13. The effect of curcumin on insulin release in rat-isolated pancreatic islets, Angiology, 2010, vol. 61, no. 6, pp. 557–566.
  14. Novel water-soluble curcumin derivative mediating erectile signaling, Journal of Sexual Medicine, 2010, vol. 7, no. 8, pp. 2714–2722.
  15. Effects of Losartan, HO-1 Inducers or HO-1 inhibitors on erectile signaling in diabetic rats, Journal of Sexual Medicine, 2009, vol. 6, no. 12, pp. 3254–3264.
  16. The role of PDE5 inhibitors in heme oxygenase-cgmp relationship in rat cavernous tissues, Journal of Sexual Medicine, 2008, vol. 5, no. 7, pp. 1636–1645.
  17. Oral phosphodiesterase-5 inhibitors: Effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue, Andrologia, 2007, vol. 39, no. 2, pp. 66–70.
  18. Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis, Clinical Biochemistry, 2007, vol. 40, no. 12, pp. 893–899.

Awards:

  • Award of International publication in distinguished international journals for the year 2011 and 2012 From Cairo University, Egypt.
  • Distinguished Assistant Professor in teaching Medical Biochemistry and Molecular Biology from the administration of the Faculty of Medicine, Cairo University for three consecutive years (2007-2008, 2008-2009, 2009-2010).
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