Dr Cassandra Fleming

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Lecturer

Email: cassandra.fleming@aut.ac.nz

ORCID: ORCID logo  https://orcid.org/0000-0002-7730-7305

Qualifications:

  • Bachelor of Forensic Science (Honours) (Deakin University, Australia)
  • PhD (Deakin University, Australia)

Biography:

I obtained my PhD in organic chemistry in 2015 from Deakin University, Australia, under the supervision of Associate Professor Frederick Pfeffer. Following my doctorate, I moved to Sweden to work with Professor Joakim Andréasson as a postdoctoral researcher at Chalmers University of Technology, where I was involved in projects concerned with the development of fluorescent bioactives as molecular tools to probe real-time intracellular events. In 2017, I joined the group of Professor Morten Grølti at the University of Gothenburg, as a Marie Curie postdoctoral fellow, in which my work focused on the development of light responsive kinase inhibitors as molecular tools for the study of disease progression in a cellular setting. In January 2020, I joined the School of Chemistry at AUT as a lecturer.

Research Areas:

  • Light-controlled enzyme inhibition
  • Development of light-responsive drug delivery systems
  • Ligand-targeted drug delivery
  • Development of fluorescent bioactive to probe dynamic biological functions

Publications:

  • C. L. Fleming, P. A. Sandoz, T. Inghardt, B. Önfelt, M. Grøtli, J. Andréasson, A Fluorescent LCK Inhibitor that Exhibits Diagnostic Changes in Emission Upon Binding the Kinase Enzyme, Angew. Chem. Int. Ed., 2019, 58, 15000–15004. DOI: 10.1002/anie.201909536
  • C. L. Fleming, M. Grøtli, J. Andréasson, On-Command Regulation of Kinase Activity using Photonic Stimuli, ChemPhotoChem, 2019, 3, 318–326. DOI: 10.1002/cptc.201800253
  • C. L. Fleming, A. Natoil, J. Schreuders, M. Devlin, P. Yoganantharajah, Y. Gilbert, K. G. Leslie, E. J. New, T. D. Ashton, F. M. Pfeffer, Highly Fluorescent and HDAC6 Selective Scriptaid Analogues, Eur. J. Med. Chem., 2019, 162, 321–333. DOI: 10.1016/j.ejmech.2018.11.020
  • C. L. Fleming, S. Li, M. Grøtli, J. Andréasson, Shining New Light on the Spiropyran Photoswitch: A Photocage Decides between cistrans or Spiro-Merocyanine Isomerization, J. Am. Chem. Soc., 2018, 140, 43, 14069–14072. DOI: 10.1021/jacs.8b09523
  • C. L. Fleming, P. Remón, S. Li, N. Simeth, B. König, M. Grøtli, J. Andréasson, On the Use of Diarylmaleimide Derivatives in Biological Contexts: An Investigation of the Photochromic Properties in Aqueous Solution, Dyes and Pigments, 2017, 137, 410–420. DOI: 10.1016/j.dyepig.2016.10.023
  • V. Gaur, T. Connor, A. Sanigorski, S. D. Martin, C. R. Bruce, D. C. Henstridge, S. T. Bond, K. A. McEwen, L. Kerr-Bayles, T. D. Ashton, C. Fleming, M. Wu, L. S. P. Winer, D. Chen, G. M. Hudson, J. W. R. Schwabe, K. Baar, M. A. Febbraio, P. Gregorevic, F. M. Pfeffer, K. R. Walder, Mark Hargreaves, S. L. McGee, Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation, Cells Report, 2016, 16, 2802–2810. DOI: 10.1016/j.celrep.2016.08.005
  • C. L. Fleming, T. D. Nalder, E. H. Doeven, C. J. Barrow, F. M. Pfeffer, T. D. Ashton, Synthesis of N-substituted 4-Hydroxynaphthalimides Using Palladium-Catalysed Hydroxylation, Dyes and Pigments, 2016, 126, 118–120. DOI: 10.1016/j.dyepig.2015.11.2007
  • C. L. Fleming, T. D. Ashton, C. Nowell, M. Devlin, A. Natoli, J. Schreuders and F. M. Pfeffer, A Fluorescent Histone Deacetylase (HDAC) Inhibitor for Cellular Imaging, Chem. Commun., 2015, 51, 7827–7830. DOI: 10.1039/C5CC02059J
  • K. Roy, R. K. Kanwar, C. H. A. Cheung, C. L. Fleming, R. Veedu, S. Krishnakmar, J. Kanwar, Locked Nucleic Acid Modified Bi-Specific Aptamer-Targeted Nanoparticles Carrying Survivin Antagonist Towards Effective Colon Cancer Therapy, RSC Advances, 2015, 5, 29008–29016. DOI: 10.1039/C5RA0391C
  • C. L. Fleming, T. D. Ashton and F. M. Pfeffer, Synthesis of 4-Amino Substituted 1,8-Naphthalimide Derivatives using Palladium-mediated Amination, Dyes and Pigments, 2014, 109, 135–143. DOI: 10.1016/j.dyepig.2014.05.006
  • C. L. Fleming, T. D. Ashton, V. Gaur, S. L. McGee and F. M. Pfeffer, Improved Synthesis and Structural Reassignment of MC1568: A Class IIa Selective HDAC Inhibitor, J. Med. Chem., 2014, 57(3), 1132–1135. DOI: 10.1021/jm401945k
  • J. M. Altimari, J. P. Delaney, L. Servinis, J. S. Squire, M. T. Thornton, S. K. Khosa, B. M. Long, M. D. Johnstone, C. L. Fleming, F. M. Pfeffer, S. M. Hickey, M. P. Wride, T. D. Ashton, B. L. Fox, N. Byrne and L. C. Henderson, Rapid Formation of Diphenylmethyl Ethers and Thioethers Using Microwave Irradiation and Protic Ionic Liquids, Tetrahedron Letters, 2012, 53(16), 2035–2039. DOI: 10.1016/j.tetlet.2012.02.011
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